If deer is your primary game both are pretty much equal. The both have a similar trajectory and kill well within their range. The 450 IMO is a bit more accurate based on what I see different people getting on the range. They both however have more then enough accuracy that there is no handicap there if the shooter can handle the rifle. Rifles choices the same, lots of companies are chambering both in their bolt guns and AR uppers as exampleNow that you have three years under your belt, what's your view on 450 vs 350
Recoil is very different though and for the sensitive the 350 is the better choice. Ammo for the 350 has seemed to be cheaper too from what I’ve seen in the stores. If I was choosing a rifle for a teen or smaller built beginner, or if I was recoil shy, I’d definitely go with the 350.
Personally if I was doing it all over today I’d probably pick the 350. My Ruger and most other guns in 450, have muzzle brakes that make shooting from a box blind a pain in the ears, especially if you can’t get the muzzle 8+ inches out the window. That is my only real complaint of the 450. I wear electronic ears in the blind and even though they allow me to hear they also amplify wind and don’t let me discern direction.